Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages
We have designed and synthesized 16 new olean-and urs-1-en-3-one triterpenoids with various modified rings C as potential antiinflammatory and cancer chemopreventive agents and evaluated their inhibitory activities against production of nitric oxide induced by interferon-γ in mouse macrophages. This investigation revealed that 9 (11)-en-12-one and 12-en-11-one functionalities in ring C increase the potency by about 2-10 times compared ...
![(4AS,6AR,6BS,13AS,15AR,15BS)-甲基2,2,6A,6B,9,9,13A-七甲基-15-氧代-1,2,3,4,4A,5,6,6A ,6B,7,8,8A,9,13,13A,15,15A,15B-八氢十氢萘并[2,3-D]异噁唑-4A-羧酸结构式](https://image.chemsrc.com/caspic/207/218600-52-3.png)
