A novel series of 2-carboxytetrahydroquinolines provides new insights into the eastern region of glycine site NMDA antagonists

G Dannhardt, M v Gruchalla, BK Kohl…

文献索引：Dannhardt, Gerd; Gruchalla, Markus V.; Kohl, Beate K.; Parsons Archiv der Pharmazie, 2000 , vol. 333, # 8 p. 267 - 274

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被引用次数: 12

摘要

Overactivation of the N-methyl-D-aspartate (NMDA) receptor has been implicated in a huge number of acute and chronic neurodegenerative disorders. The most prominent among these include stroke, Alzheimer's disease, and epilepsy [1]. A visualization and quantification of NMDA receptor changes in these diseases by PET studies may lead to a deeper understanding of the pathogenesis. Due to their potency and high receptor ...