Fluorenylmethoxycarbonyl??N??methylamino Acids Synthesized in a Flow Tube??in??Tube Reactor with a Liquid–Liquid Semipermeable Membrane

AE Buba, S Koch, H Kunz…

文献索引：Buba, Annette E.; Koch, Stefan; Kunz, Horst; Loewe, Holger European Journal of Organic Chemistry, 2013 , # 21 p. 4509 - 4513

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被引用次数: 10

摘要

Abstract Both steps of the N-methylation of 9-fluorenylmethoxycarbonyl (Fmoc) amino acids were carried out in a microstructured tube-in-tube reactor equipped with a semipermeable Teflon® AF 2400 membrane as the inner tubing. In the first step, gaseous formaldehyde was passed through the inner membrane to effect the acid-catalyzed conversion of the Fmoc amino acids into the corresponding N-Fmoc oxazolidinones. In the second step, liquid– ...