1-(2-Aminoethyl)-6-aryl-4H-[1, 2, 4] triazolo [4, 3-a][1, 4] benzodiazepines with diuretic and natriuretic activity

JB Hester, JH Ludens, DE Emmert…

文献索引：Hester, Jackson B.; Ludens, James H.; Emmert, D. Edward; West, Bruce E. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1157 - 1163

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被引用次数: 40

摘要

A series of 1-(2-aminel-phenylethy1)-6-phenyl-W-[1, 2, 4] triazolo [4, 3-a][1, 4] benzodiazepines was prepared and evaluated for diuretic activity. These compounds have diuretic and natriuretic activity but no kaliuretic activity when evaluated by oral administration to the conscious rat. The structure requirements for this activity are discussed. In particular it was found that the 2-aminoethyl side chain at C-1 with hydrogen or methyl substituents on ...