Journal of medicinal chemistry

Irreversible enzyme inhibitors. CLXVII. Thymidine phosphorylase. 10. On the nature and dimensions of the hydrophobic bonding region. A

BR Baker, SE Hopkins

文献索引：Journal of medicinal chemistry, , vol. 13, # 1 p. 87 - 89

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被引用次数: 8

摘要

... but wa9 300- fold less effective on the E. colz B enzyme; such species differences in binding to a hydrophobic bonding region adjacent to the active site have been previously ob- served with dihydrofolate reductase.' Chemistry.-The 6 ... I) E. 13. ... 1'. I?rundage, and L. Fletcher, J . .in!. ...