Synthesis and anti-HIV activity of 4'-thio-2', 3'-dideoxynucleosides

…, RM Riggs, KN Tiwari, JA Montgomery

文献索引：Secrist, John A.; Riggs, Robert M.; Tiwari, Kamal N.; Montgomery, John A. Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 533 - 538

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被引用次数: 82

摘要

In hopes of finding better therapeutic agents for AIDS, a wide variety of sugar-modified nucleosides have been prepared. Thionucleosides in which oxygen of the sugar ring has been replaced by sulfur have shown interesting biological a~ tivities.“~ It has been demonstrated that 4 '-thioadenosine, which is a potent inhibitor of S-adenosylhomocysteine hydrolase, e rapidly undergoes phosphorylation to ita triphosphate. The resistance of ...