2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents

GP Vallerini, L Amori, C Beato, M Tararina…

文献索引：Vallerini, Gian Paolo; Amori, Laura; Beato, Claudia; Tararina, Margarita; Wang, Xiao-Dan; Schwarcz, Robert; Costantino, Gabriele Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9482 - 9495

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被引用次数: 6

摘要

3-Hydroxyanthranilic acid 3, 4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observed in several neurodegenerative diseases, but pharmacological investigation on its role in the pathogenesis of these conditions is difficult because only one class of substrate-analogue 3-HAO inhibitors, with poor chemical stability, has been ...