Synthesis and evaluation of adenosine antagonist activity of a series of [1, 2, 4] triazolo [1, 5-c] quinazolines

…, C López, JM Brea, F Fernánde, O Caamaño

文献索引：Balo, Carmen; Lopez, Carmen; Brea, Jose Manuel; Fernandez, Franco; Caamano, Olga Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 3 p. 372 - 375

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被引用次数: 11

摘要

A series of [1, 2, 4] triazolo [1, 5-c] quinazolines were prepared in satisfactory yields by reaction of some derivatives of 2-aminobenzohydrazide with several hydrochlorides of aromatic amidines, and their binding affinities for the recombinant human adenosine A 2A and A 2B receptors were determined. None of the new compounds showed noteworthy affinity for these receptors, though a very high affinity for the A 2A receptor and, ...