Preparation and antitumor activity of new mitomycin A analogs

…, BS Iyengar, WA Remers, WT Bradner

文献索引：Sami, Salah M.; Iyengar, Bhashyam S.; Remers, William A.; Bradner, William T. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 168 - 173

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被引用次数: 15

摘要

A'series of 26 mitomycin A analogues including 23 new ones was prepared by a variety of methods. The most useful methods were alkoxide exchange on mitomycin A and treatment of 7-hydroxymitosane with 3-substituted 1-phenyltriazenes. Many of the new analogues were superior to mitomycin C in the P388 leukemia assay and the more stringent subcutaneous B16 melanoma assay both in mice. Four of them gave long-term survivors ...