… , synthesis, and biological evaluation of substituted-N-(thieno [2, 3-b] pyridin-3-yl)-guanidines, N-(1H-pyrrolo [2, 3-b] pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)- …

…, DN Patel, VM Prajapati, AA Gupta, PA Jadav…

文献索引：Bahekar, Rajesh H.; Jain, Mukul R.; Goel, Ashish; Patel, Dipam N.; Prajapati, Vijay M.; Gupta, Arun A.; Jadav, Pradip A.; Patel, Pankaj R. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 9 p. 3248 - 3265

全文：HTML全文

被引用次数: 34

摘要

Sulfonylureas stimulate insulin secretion independent of the blood glucose concentration and therefore cause hypoglycemia in type 2 diabetic patients. Over the last years, a number of aryl-imidazoline derivatives have been identified that stimulate insulin secretion in a glucose-dependent manner. In the present study, we have developed three series of substituted N-(thieno [2, 3-b] pyridin-3-yl)-guanidine (2a–l), N-(1H-pyrrolo [2, 3-b] pyridin-3 ...