Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors

CM Abuhaie, A Ghinet, A Farce, J Dubois…

文献索引：Abuhaie, Cristina-Maria; Ghinet, Alina; Farce, Amaury; Dubois, Joelle; Rigo, Benoit; Bicu, Elena Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5887 - 5892

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被引用次数: 8

摘要

Abstract A new family of 30 benzoylated N-ylides 4 and 5 was synthesized and evaluated for the inhibitory activity on human protein farnesyltransferase. Most of these novel compounds possessed in vitro inhibition potencies in the micromolar range. The nature of the ...