Synthesis and evaluation of chalcone derivatives as inhibitors of neutrophils' chemotaxis, phagocytosis and production of reactive oxygen species

…, VJ Benedict, KW Lam, I Jantan, J Jalil…

文献索引：Bukhari, Syed N. A.; Tajuddin, Yasmin; Benedict, Vannessa J.; Lam, Kok W.; Jantan, Ibrahim; Jalil, Juriyati; Jasamai, Malina Chemical Biology and Drug Design, 2014 , vol. 83, # 2 p. 198 - 206

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被引用次数: 11

摘要

Inhibitory effects on neutrophils' chemotaxis, phagocytosis and production of reactive oxygen species (ROS) are among the important targets in developing antiinflammatory agents and immunosuppressants. Eight series of chalcone derivatives including five newly synthesized series were assessed for their inhibitory effects on chemotaxis, phagocytosis and ROS production in human polymorphonuclear neutrophils (PMNs). Inhibition of PMNs ...