1, 3-Dihydro-2H-imidazo [4, 5-b] quinolin-2-ones-inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation

…, DL Wedding, JJK Wright, JS Fleming…

文献索引：Meanwell; Roth; Smith; Wedding; Wright; Fleming; Gillespie Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2906 - 2916

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被引用次数: 30

摘要

A series of 1, 3-dihydro-2H-imidazo [4, 5-b] quinolin-2-one derivatives was synthesized and evaluated as inhibitors of cAMP hydrolysis by a crude human platelet phosphodiesterase preparation and as inhibitors of ADP-and collagen-induced aggregation of rabbit blood platelets. The parent structure 7a, demonstrated potent inhibitory activity that was enhanced by the introduction of alkyl, alkoxy, or halogen substituents at the 5-, 6-, 7-, and% positions ...