Tetrahedron letters

A facile synthesis of aromatic trifluoromethyl compounds via orthothio esters

DP Matthews, JP Whitten, JR McCarthy

文献索引：Matthews, Donald P.; Whitten, Jeffrey P.; McCarthy, James R. Tetrahedron Letters, 1986 , vol. 27, # 40 p. 4861 - 4864

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被引用次数: 36

摘要

Abstract Aromatic trifluoromethyl compounds (2) are prepared by treatment of aromatic orthothio esters (1) with 1, 3-dibromo-5, 5-dimethylhydantoin (DBH) or N-bromosuccinimide (NBS) followed by HF/pyridine complex. The starting materials (1) were readily obtained by literature methodology.