Syntheses of Antitumor Morphinane Alkaloids, Sinococuline and 6-epi-, 7-epi-, and 6-epi-7-epi-Sinococuline, from Sinomenine

Y Hitotsuyanagi, K Nishimura, H Ikuta…

文献索引：Hitotsuyanagi, Yukio; Nishimura, Kunihiko; Ikuta, Hiroshi; Takeya, Koichi; Itokawa, Hideji Journal of Organic Chemistry, 1995 , vol. 60, # 14 p. 4549 - 4558

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被引用次数: 17

摘要

We have previously reported2 the isolation and structure elucidation of an antitumor alkaloid, sinococuline (l), from the native Japanese plant Cocculus trilobus. Sinococuline (1) is characterized by a morphinane skeleton possessing a unique oxidation state on ring C and promising antitumor activity against animal tumor models. However, the variable content in the plant and the difficult isolation and purification process due to its highpolar, ...