The Journal of organic chemistry

Cross-coupling of alkynylsilanols with aryl halides promoted by potassium trimethylsilanolate

SE Denmark, SA Tymonko

文献索引：Denmark, Scott E.; Tymonko, Steven A. Journal of Organic Chemistry, 2003 , vol. 68, # 23 p. 9151 - 9154

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被引用次数: 40

摘要

The palladium-catalyzed cross-coupling of aliphatic alkynylsilanols with aryl iodides has been demonstrated with potassium trimethylsilanolate as the coupling promoter and copper (I) iodide as a cocatalyst. The cross-coupling proceeds at room temperature in good to excellent yield with a range of aryl iodides. A comparison of the reactivity of alkynylsilanols, trimethylsilylalkynes, and terminal alkynes under fluoride and fluoride-free conditions was ...