The addition of methoxypyridinecarboxaldehydes to certain lithium dialkylamides gave a- amino alkoxides in situ that were ring-lithiated with alkyllithium bases. Alkylation and hydrolysis on workup provided ringsubstituted methoxypyridinecarboxaldehydes via a one- pot reaction. The one-pot methylation of isomeric methoxypyridinecarboxaldehydes was examined. The regioselectivity of the lithiation-methylation was dependent on the ...
