Synthesis of (trimethylsilyl) thiazoles and reactions with carbonyl compounds. Selectivity aspects and synthetic utility

…, M Fogagnolo, A Medici, P Pedrini

文献索引：Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1748 - 1761

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被引用次数: 110

摘要

Synthetic routes to all possible regioisomeric mono-and bis (trimethylsily1) thiazoles as well as to the tris-(trimethylsilyl) derivative via lithiation-silylation sequences of the thiazole ring followed by selective protcdesilylation in some cases are described.(Trimethylsily1) thiaoles serve as thiazolyl donor synthons upon reaction with carbonyl compounds (ketenes, acyl chlorides, aldehydes) for the preparation of mono-and bis-substituted thiazoles in very ...