The Journal of Organic Chemistry

Synthesis of bridgehead fluorides by fluorodeiodination

EW Della, NJ Head

文献索引：Della, Ernest W.; Head, Nicholas J. Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2850 - 2855

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被引用次数: 37

摘要

Fluorodeiodination is found to be an attractive procedure for the synthesis of bridgehead fluorides. Thus, treatment of the corresponding iodide with xenon difluoride in dichloromethane at ambient temperature generally leads to high yields of the fluoride. Evidence suggests the intermediacy of the bridgehead cation in this reaction, and accordingly the substrates which are unfavorably disposed to fluorodeiodination are the ...