4-Aroyl-1, 3-dihydro-2H-imidazol-2-ones: a new class of cardiotonic agents. 2. Effect of 4-pyridoyl substituents and related compounds

RA Schnettler, RC Dage…

文献索引：Schnettler, Richard A.; Dage, Richard C.; Palopoli, Frank P. Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 860 - 862

全文：HTML全文

被引用次数: 14

摘要

Recent reports, from this laboratory, have described the cardiovascular activity of the 4-aroyl- 1, 3-dihydro-2H-imidazol-2-0nes.~,~ Marked positive inotropic activity accompanied by minor positive chronotropic and hypotensive effects were found for a large number of these compounds. The combination of positive inotropic activity and after-load reduction suggested that these compounds may have beneficial effects in the treatment of ...