Synthesis and gastrointestinal prokinetic activity of novel benzamide derivatives with amphoteric side chains.

J Sakaguchi, N Iwasaki, Y Iwanaga, T Saito…

文献索引：Sakaguchi; Iwasaki; Iwanaga; Saito; Takahara; Kato; Hanaoka Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 4 p. 424 - 436

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被引用次数: 11

摘要

Novel benzamide derivatives (19-24, 32a-c, 43d-f), each possessing a cycloaminoalkanecarboxylic acid side chain, were synthesized and their gastrointestinal prokinetic and dopamine D 2 receptor antagonist activities were evaluated. 4-[(4-Amino-5- chloro-2-methoxybenzoyl) amino]-1-piperidineacetic acid (19) exhibited the most potent gastro-and colon-prokinetic activities, through intravenous administration to conscious ...