Steroids

Synthesis and testing of 17aβ-hydroxy-7α-methyl-d-homoestra-4, 16-dien-3-one: a highly potent orally active androgen

MA Avery, M Tanabe, DF Crowe, G Detre, RH Peters…

文献索引：Avery, Mitchell A.; Tanabe, Masato; Crowe, David F.; Detre, George; Peters, Richard H.; Chong, Wesley K. M. Steroids, 1990 , vol. 55, # 2 p. 59 - 64

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被引用次数: 13

摘要

Abstract The title compound, 17aβ-hydroxy-7α-methyl-d-homoestra-4, 16-dien-3-one (3), was synthesized in five steps (17% overall yield) from 7α-methylestrone methyl ether (5) and was found to possess oral androgenic activity, in excess of other known androgens, without using 17α-alkyl substitution.(Steroids 55: 59–64, 1990)