Tetrahedron letters

A versatile method for the synthesis of (S)-or (R)-cycloalkylglycines,(S)-or (R)-N-Heterocyclic and α, β-unsaturated N-heterocyclic α-amino acids

R Pauly, NA Sasaki, P Potier

文献索引：Pauly, Regine; Sasaki, N. Andre; Potier, Pierre Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240

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被引用次数: 39

摘要

Abstract Two different types of cyclic α-amino acids, cycloalkylglycines and N-heterocyclic α- amino acids, were prepared in optically pure form from the same chiral synthon 1-(R)(or 1- (S)) simply by altering the quantity or type of base required for anion formation. Elaboration of the heterocyclic intermediate 3 provided α, β-unsaturated N-heterocyclic α-amino acids.