Development and characterization of glutamyl-protected N-hydroxyguanidines as reno-active nitric oxide donor drugs with therapeutic potential in acute renal failure

…, DJ Webb, NP Botting, IL Megson

文献索引：Zhang, Qingzhi; Kulczynska, Agnieszka; Webb, David J.; Megson, Ian L.; Botting, Nigel P. Chemical Communications, 2013 , vol. 49, # 14 p. 1389 - 1391

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被引用次数: 3

摘要

Acute renal failure (ARF) has high mortality and no effective treatment. Nitric oxide (NO) delivery represents a credible means of preventing the damaging effects of vasoconstriction, central to ARF, but design of drugs with the necessary renoselectivity is challenging. Here, we developed N-hydroxyguanidine NO donor drugs that were protected against spontaneous NO release by linkage to glutamyl adducts that could be cleaved by γ- ...