Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

…, M Fehr, M Habermeyer, A Hofmann, KH Merz…

文献索引：Baechler, Simone A.; Fehr, Markus; Habermeyer, Michael; Hofmann, Andreas; Merz, Karl-Heinz; Fiebig, Heinz-Herbert; Marko, Doris; Eisenbrand, Gerhard Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 3 p. 814 - 823

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被引用次数: 19

摘要

The plant alkaloid lycobetaine has potent topoisomerase-targeting properties and shows anticancer activity. Based on these findings, several lycobetaine analogs were synthesized mainly differing in their substituents at 2, 8 and 9 position and their biological activities were evaluated. The topoisomerase-targeting properties and cytotoxicity of these structural analogs were assessed in the human gastric carcinoma cell line GXF251L. Performing a ...