Synthesis of possible metabolites of chlorpromazine. III. 7, 8??Disubstituted chlorpromazine derivatives

EA Nodiff, K Tanabe, F Schnierle…

文献索引：Nodiff,E.A. et al. Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 203 - 208

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被引用次数: 9

摘要

Cyanoethylation of 5 (Scheme 2) and catalytic hydrogenation of the cyanoethyl compound (12) produced the norz derivative (13). A single attempt to obtain 13 by reduction of 14 was unsuccessful. The Goldberg reaction (15) between 3-chloroacetanilide (15) and 4- bromoveratrole (16) initiated the synthesis of 7, 8-dimethoxychlorpromazine hydrochloride (1 9)(Scheme