A further series of linear hexamethylene-NNN-trisonium compounds has been synthesised and tested for neuromuscular blocking activity. In the alkyl-substituted derivatives, at least one Et is required for significant potency in mammals. Apart from the Et, Bun and EtBut compounds, larger alkyl substituents lower potency. High potency in mammals requires at least two Et groups on the terminal nitrogens, if the third group is not Me. Only weak ...
