Spironolactone (I), an aldosterone antagonist introduced in the late 1950s is a high-volume diuretic and belongs to a growing class of steroidal spirolactones.'Our interest in this class of lactones has lead us to develop a new approach to spironolactone from the readily available acetylene adduct 2. We thought that hydroformylation2 of ethisterone 2 would lead to the lactol3, which would give lactone 8 upon oxidation. Initial attempts at hydroformylating ...
![5'-hydroxyspiro[pregnane-17,2'-tetrahydrofuran]-5-en-3-one结构式](https://image.chemsrc.com/caspic/151/121936-43-4.png)
