Exploring the synthetic applicability of a cyanobacterium nitrilase as catalyst for nitrile hydrolysis

C Mukherjee, D Zhu, ER Biehl…

文献索引：Mukherjee, Chandrani; Zhu, Dunming; Biehl, Edward R.; Hua, Ling European Journal of Organic Chemistry, 2006 , # 23 p. 5238 - 5242

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被引用次数: 11

摘要

Abstract The substrate specificity and synthetic applicability of the nitrilase from cyanobacterium Synechocystis sp. strain PCC 6803 have been examined. This nitrilase catalyzed the hydrolysis of both aromatic and aliphatic nitriles to the corresponding acids in high yields. Furthermore, the stereoselective hydrolysis of phenyl-substituted β-hydroxy nitriles to (S)-enriched β-hydroxy carboxylic acids and selective hydrolysis of α, ω-dinitriles ...