Piperazinylimidazo [1, 2-a] pyrazines with selective affinity for in vitro. alpha.-adrenergic receptor subtypes

WC Lumma Jr, WC Randall, EL Cresson…

文献索引：Lumma Jr.; Randall; Cresson; Huff; Hartman; Lyon Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 357 - 363

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被引用次数: 52

摘要

Regioselective syntheses of alkyl-and halogen-substituted piperazinylimidazo [1, 2-a] pyrazines by novel oxidationdehydration of [(@-hydroxyalkyl) amino] pyrazines are described. Lanthanide shift reagent studies allowed correction of literature assignments of NMR chemical shifts and coupling constants for the imidazo [1, 2-a] pyrazine ring system (eg, J5, 8> J6, J. Equilibrium constants for displacement of specifically bound [3H] ...