Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors

C Han, Z Huang, C Zheng, L Wan, Y Lai, S Peng…

文献索引：Han, Chun; Huang, Zhangjian; Zheng, Chao; Wan, Ledong; Lai, Yisheng; Peng, Sixun; Ding, Ke; Ji, Hongbin; Zhang, Yihua European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 82 - 90

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被引用次数: 5

摘要

Abstract To search for potent nitric oxide (NO) donating epidermal growth factor receptor (EGFR) inhibitors, a series of phenylsulfonylfuroxan-based anilinopyrimidines 10a–h were synthesized and biologically evaluated. Compounds 10f–h exhibited potent inhibitory activity against EGFR L858R/T790M and were as potent as WZ4002 in inhibition of H1975 cells harboring EGFR L858R/T790M. Additionally, 10h produced high levels of NO in ...