New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity

BM Swahn, A Claesson, B Pelcman, Y Besidski…

文献索引：Swahn, Britt-Marie; Claesson, Alf; Pelcman, Benjamin; Besidski, Yevgeni; Molin, Hakan; Sandberg, Mats P.; Berge, Odd-Geir Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 14 p. 1635 - 1640

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被引用次数: 19

摘要

The synthesis and the NMDA receptor binding affinities of α-amino-3-(phosphonomethyl)-2- naphthalene-propanoic acid, α-amino-3-(phosphonomethyl)-2-benzofuranpropanoic acid, a series of substituted (R)-α-amino-3-(phosphonomethyl)-2-quinolinepropanoic acids,(R)-α- amino-3-(phosphonomethyl)-1, 8-naphthyridine-2-propanoic acid and (R)-α-amino-3- (phosphonomethyl)-1, 6-naphthyridine-2-propanoic acid are reported.