Tetrahedron

Total synthesis of peumusolide A, NES non-antagonistic inhibitor for nuclear export of MEK

S Tamura, S Doke, N Murakami

文献索引：Tamura, Satoru; Doke, Shunsuke; Murakami, Nobutoshi Tetrahedron, 2010 , vol. 66, # 43 p. 8476 - 8480

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被引用次数: 7

摘要

The first total synthesis of peumusolide A (1) has been achieved by combination of regio- and stereo-selective aluminum-mediated hydroiodination to 2-yn-1-ol and enantioselective reduction of 4-en-1-yn-3-one with the chiral oxazaborolidine as the key reactions. This total synthesis has unequivocally established our proposed absolute structure of 1.