Scheme I1 a'0 lysis? Several methods have been developed for the synthesis of 2- aminochromones 1 (Scheme I). Vilsmeier condensation of a &amido ester with phenol (path a) 4 or amine displacement of a 3-bromochromone 2 (path b) 5 suffer from either unacceptably low yields or difficult chromatographic separations of complex mixtures. The more practical Bantick procedure, starting from a 2'-hydroxyacetophenone, proceeds ...
