Synthesis and antihypertensive activity of a series of 4-amino-6, 7-dimethoxyquinazoline derivatives

…, AP Dumas, F Lefevre-Borg, I Cavero

文献索引：Manoury; Binet; Dumas; Lefevre-Borg; Cavero Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 19 - 25

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被引用次数: 54

摘要

36-38, 45-47 conversion of N-benzylamino alcohols into N-benzylalkanediamines, which were acylated and then debenzylated by catalytic hydrogenation to yield 36-38 and 45-47 (method D). The N-acylpropanediamines (R, or R2= H) were synthesized by a different route (Scheme IV, method E), namely, by using the 3-(methy1amino) propanenitrile as the starting material, which was first acylated and then reduced to provide a mixture of primary and ...