Tetrahedron Letters

A mild and efficient one-pot synthesis of 1-hydroxymethylene-1, 1-bisphosphonic acids. Preparation of new tripod ligands

M Lecouvey, I Mallard, T Bailly, R Burgada, Y Leroux

文献索引：Lecouvey, Marc; Mallard, Isabelle; Bailly, Theodorine; Burgada, Ramon; Leroux, Yves Tetrahedron Letters, 2001 , vol. 42, # 48 p. 8475 - 8478

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被引用次数: 76

摘要

A simple and efficient one-pot procedure for synthesis of 1-hydroxymethylene-1, 1- bisphosphonic acids by reaction of acyl chlorides and tris (trimethylsilyl) phosphite is described. This method was applied to the synthesis of new phosphonated chelating tripod ligands.