Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase

…, NV Nikolaus, M Witvrouw, Z Debyser…

文献索引：Adams, Martina M.; Bats, Jan W.; Nikolaus, Nadja V.; Witvrouw, Myriam; Debyser, Zeger; Engels, Joachim W. Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 7 p. 978 - 990

全文：HTML全文

被引用次数: 9

摘要

Abstract Six fluoroquinolone ribonucleosides were synthesized by using microwave irradiation starting from fluoroanilines. In most cases the microwave application proved superior in time and yield, especially the one step decarboxylation of the carboxyquinolone esters 3a-3c and the Vorbrüggen glycosylation. The former led to the new type of fluoroquinolone ribosides 8a-8c. Compound 8c in the crystal structure showed C3'-endo ...