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2-(Alkoxyaryl)-2-imidazoline monoamine oxidase inhibitors with antidepressant activity

M Harfenist, FE Soroko…

文献索引:Harfenist,M. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 405 - 409

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被引用次数: 33

摘要

Unlike the related noncyclic amidines which are broad-spectrum cestocides, a number of 2- imidazolines substituted in the 2 position by alkoxyaryl groups were not highly active in screening tests against the mouse tapeworms Hymenolepis nana and Oochoristica symmetrica. Certain of the 2-(4-alkoxynaphthyl)-2-imidazolines and 2-(6-alkoxy-2-naphthyl)- 2-imidzolines, however, had activity interpreted as antidepressant in the mouse. This ...