Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3', 4'-dihydroxynomifensine

…, C Kaiser, M Brenner, D Gaitanopoulos…

文献索引：Dandridge; Kaiser; Brenner; Gaitanopoulos; Davis; Webb; Foley; Sarau Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 28 - 35

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被引用次数: 70

摘要

3', 4'-Dihydroxynomifensine, 8-amino-1, 2, 3, 4-tetrahydro-4-(3, 4-dihydroxyphenyl)-2- methylisoquinoline (la), is an agonist of dopamine receptors in central and peripheral systems. Since this dopamine receptor agonist bears an asymmetric center at position 4, its synthesis and resolution were undertaken as part of a study directed toward determining the mode of interaction of these agents with the receptor (s). The enantiomers of 3', 4'- ...