Synthesis and antifungal activity of 2/3-arylthio-and 2, 3-bis (arylthio)-5-hydroxy-/5-methoxy-1, 4-naphthoquinones

…, JY Shim, MJ Chae, IH Choi, JY Han, OJ Jung…

文献索引：Ryu, Chung-Kyu; Shim, Ju-Yeon; Mi, Jin Chae; Ik, Hwa Choi; Han, Ja-Young; Jung, Ok-Jai; Jung, Yoon Lee; Seong, Hee Jeong European Journal of Medicinal Chemistry, 2005 , vol. 40, # 5 p. 438 - 444

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被引用次数: 41

摘要

2/3-Arylthio-and 2, 3-bis (arylthio)-5-hydroxy-/5-methoxy-1, 4-naphthoquinones 5–9 were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. The synthesized compounds 5–9 generally showed good activities against Candida albicans and C. tropicalis. The results suggest that the 1, 4- naphthoquinones 5–9 would be potent antifungal agents.