Tetrahedron Letters

Synthesis of benzimidazoles from 1, 1-dibromoethenes

W Shen, T Kohn, Z Fu, XY Jiao, S Lai, M Schmitt

文献索引：Shen, Wang; Kohn, Todd; Fu, Zice; Jiao, XianYun; Lai, Sujen; Schmitt, Michael Tetrahedron Letters, 2008 , vol. 49, # 51 p. 7284 - 7286

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被引用次数: 16

摘要

A mild and efficient method for the preparation of substituted benzimidazoles from 1, 1- dibromoethenes and o-diaminobenzenes is described. The reaction employs DABCO as the base and NMP as the solvent. A variety of substitutions on both 2-aryl-1, 1-dibromoethenes and o-diaminobenzenes are tolerated. This new procedure is carried out under mildly basic conditions, which may provide a complementary route to the existing preparations of ...