The synthesis of the two enantiomers of 1-(3-bromo-5-isoxazoly1)-2-(tert-butylamino) ethanol (l), a potent and selective &adrenergic stimulant, has been efficiently accomplished by enzyme-catalyzed transformations. The absolute configurations are attributed to (+)-and (- )-1 by correlation with@)-3-butyn-2-01. The S enantiomer was prepared in> 98% enantiomeric excess by reducing a-bromo ketone 4 in the presence of alcohol ...
