Retinoic acid analogs with ring modifications. Synthesis and pharmacological activity

MI Dawson, PD Hobbs, RLS Chan…

文献索引：Dawson; Hobbs; Chan; Chao Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1214 - 1223

全文：HTML全文

被引用次数: 34

摘要

Analogues of retinoic acid that have their major modifications in the 5, 6 double bond and 4- methylene group regions of the Bcyclogeranylidene ring have hen synthesid 88 potential agents for the tzeatment and prevention of epithelial cancer. Thw modifications were intended to duce retinoid toxicity by lowering the effective treatment dose becaw the major metabolic deactivation pathway would be inhibited. Ethyl (E)-3, 7-dimethyl-9-(ezo-2- ...