Synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring

…, WB Im, JK Rhee, MJ Shim, WB Kim, EC Choi

文献索引：Jo, Yeong Woo; Im, Weon Bin; Rhee, Jae Keol; Shim, Mi Ja; Kim, Won Bae; Choi, Eung Chil Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5909 - 5915

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被引用次数: 82

摘要

A series of oxazolidinone derivatives, which morpholino group of linezolid was replaced with heteroaromatic ring substituted pyridine moiety, were newly synthesized, and their substituted effects on in vitro and in vivo antibacterial activities were evaluated against four problematic gram-positive strains including drug resistant strains and two gram-negative strains. Most compounds exhibited the enhanced in vitro activities with 4–16-fold and ...