Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents

…, IA Al-Suwaidan, SG Abdel-Hamide, TZ Shawer…

文献索引：Alanazi, Amer M.; Abdel-Aziz, Alaa A.-M.; Al-Suwaidan, Ibrahim A.; Abdel-Hamide, Sami G.; Shawer, Taghreed Z.; El-Azab, Adel S. European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 446 - 454

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被引用次数: 17

摘要

Abstract A novel series of 6-chloro-2-p-tolylquinazolinone and substituted-(4- methylbenzamido) benzamide (1–20) were designed, synthesized and evaluated for their in- vitro antitumor activity. Compounds 3, 14 and 16 possessed remarkable broad-spectrum antitumor activity. Compound 16 was found to be a particularly active growth inhibitor of the renal cancer (GI 50= 4.07 μM), CNS cancer (GI 50= 7.41 μM), ovarian cancer (GI 50= 7.41 ...