Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists

…, GJ Stabley, RN DeHaven, N Conway-James…

文献索引：Chu, Guo-Hua; Gu, Minghua; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel. J.; DeHaven, Robert N.; Conway-James, Nathalie; Koblish, Mike; Little, Patrick J.; DeHaven-Hudkins, Diane L.; Dolle, Roland E. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 645 - 648

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被引用次数: 6

摘要

During our screening of a combinatorial library, we identified aryloxyacetamides (eg, 1 and 2) as highly potent κ-agonists. 11 Based on these lead compounds, we recently reported the design and synthesis of two novel series of constrained aryloxyacetamides 3. 12 In this communication, we report a novel series of phenylamino acetamide derivatives with the general structure I, which are bioisosteres of aryloxyacetamides with the replacement of oxygen ...