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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

An improved, scalable, and impurity-free process for tolterodine tartrate

…, N Srinivasan, KS Reddy, M Ramakrishna…

文献索引：Srinivas, Keesari; Srinivasan, Neti; Reddy, Kikkuru Srirami; Ramakrishna, Muddasani; Reddy, Chinta Raveendra; Arunagiri, Muthulingam; Kumari, Routhu Lalitha; Venkataraman, Sundaram; Mathad, Vijayavitthal T. Organic Process Research and Development, 2005 , vol. 9, # 3 p. 314 - 318

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被引用次数: 21

摘要

Tolterodine tartrate is an anticholinergic muscle relaxant used to treat urinary frequency, urinary urgency, and incontinence in people with unstable bladders. An improved, cost- effective, and impurity-free process for tolterodine tartrate suitable for large-scale commercial production is described here by addressing various scale-up and impurity issues.

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6-甲基-4-苯基色满-2-酮

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4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate结构式

methyl 3-(2-ben...

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4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

Benzenepropanol, 5-methyl-γ-phenyl-2-(phenylmethoxy)结构式

Benzenepropanol...

~%

4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate结构式

3-(2-benzyloxy-...

~%

4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate结构式

3-(2-benzyloxy-...

托特罗定单异丙基酯结构式

托特罗定单异丙基酯

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4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

肉桂酸结构式

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4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

对甲酚结构式

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4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

4-methyl-2-[3-[[3-(5-methyl-2-phenylmethoxyphenyl)-3-phenylpropyl]-propan-2-ylamino]-1-phenylpropyl]phenol结构式

4-methyl-2-[3-[...

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托特罗定杂质22结构式

托特罗定杂质22

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托特罗定杂质22结构式

托特罗定杂质22

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托特罗定杂质22结构式

托特罗定杂质22

6-甲基-4-苯基色满-2-酮结构式

6-甲基-4-苯基色满-2-酮

~%

托特罗定杂质22结构式

托特罗定杂质22

methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate结构式

methyl 3-(2-ben...

~%

托特罗定杂质22结构式

托特罗定杂质22

Benzenepropanol, 5-methyl-γ-phenyl-2-(phenylmethoxy)结构式

Benzenepropanol...

~%

托特罗定杂质22结构式

托特罗定杂质22

Benzenepropanamine, 5-methyl-N-(1-methylethyl)-γ-phenyl-2-(phenylmethoxy)结构式

Benzenepropanam...

~%

托特罗定杂质22结构式

托特罗定杂质22

3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate结构式

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托特罗定杂质22结构式

托特罗定杂质22

3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate结构式

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托特罗定单异丙基酯结构式

托特罗定单异丙基酯

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托特罗定杂质22结构式

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Benzenepropanamine, 5-methyl-N-(1-methylethyl)-γ-phenyl-2-(phenylmethoxy)结构式

Benzenepropanam...

~87%

托特罗定单异丙基酯结构式

托特罗定单异丙基酯

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托特罗定单异丙基酯结构式

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~%

托特罗定单异丙基酯结构式

托特罗定单异丙基酯

methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate结构式

methyl 3-(2-ben...

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托特罗定单异丙基酯结构式

托特罗定单异丙基酯

Benzenepropanol, 5-methyl-γ-phenyl-2-(phenylmethoxy)结构式

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托特罗定单异丙基酯结构式

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3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate结构式

3-(2-benzyloxy-...

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托特罗定单异丙基酯结构式

托特罗定单异丙基酯