Abstract A convergent total synthesis of the antibiotic macrolide myxovirescin A 1 (1) is described that is largely based on reagent-and catalyst-controlled transformations. This includes a highly regioselective Negishi reaction of dibromo-alkene 48 with an alkynylzinc reagent, and a palladium catalyzed alkyl-Suzuki coupling of the resulting enyne derivative 12 with the 9-BBN-adduct derived from alkene 61. The latter was obtained via an ...
