Synthesis of 2??chloro??5??hydroxynicotinonitrile: The required intermediate in the total synthesis of a hydroxylated metabolite of (S)??2??(3??t??butylamino??2?? …

…, EL Engelhardt, MB Freedman…

文献索引：Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J. Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448

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被引用次数: 1

摘要

Abstract A convenient method for the synthesis of 2-chloro-5-hydroxynicotinonitrile (10) via 5- amino-2-chloro-3-methylpyridine (3) is described. Subsequent conversions provided the basic metabolite 2 of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine (1). 13 C ...