60 X= CN 6 b X= C02H for many years the only antibiotic known to be derived from aklavinone (la). 3 Beginning in 1975, Oki et al. published a series of papers describing the isolation, characterization, and biological activity of seven new antibiotics with la as the agly~ on.~ One of these, aclacinomycin A (IC) is presently undergoing clinical evaluation since it has been found to have substantial anticancer activity while being less toxic than ...
